Albert,
Great to see that somebody replied. This problem puzzles me as well. To add some more info: when I send beacons, they seem to go OK (PSK Reporter shows this). The problem shows when I try to reply to somebody's CQ. The radio goes to USB, the PTT switches it to TX, but the output signal is none, because entry from mirophone is expected. I do not understand which file you refer to as the "COM". The CAT commands file is V13, the VarAC is V8.4.4, the Windows version is 10. I am suspicious of one entry in VarAC INI file (see attached picture). It states that the USB mode should be USB, rather than e.g. DATA_U.
I will be happy to replace this in the INI file, but I do not know how the DATA_U mode is called in the program vocabulary.
73, Marek sp5isz